In this week’s episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante cover potential anti-aging interventions that are on the cutting edge. They share the latest research surrounding testosterone replacement therapy (TRT), human growth hormone (HGH), peptide supplementation, exosomes, stem cells, and cellular reprogramming. The idea of human rejuvenation and potential paths towards resetting the aging clock is also discussed. #DavidSinclair #Longevity #Lifespan Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Levels - https://levels.link/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Lifespan podcast website: https://www.lifespanpodcast.com/ Dr. David Sinclair Social: Instagram - https://www.instagram.com/davidsinclairphd Twitter - https://twitter.com/davidasinclair Facebook - https://www.facebook.com/davidsinclairphd Matthew LaPlante's Social: Twitter - https://twitter.com/mdlaplante Stay up to date with David's work to democratize biological age testing and insights: https://www.tallyhealth.com/ Timestamps: 00:00:00 Kicking Off Episode Five: Interventions on the Cutting Edge 00:02:39 Expressing Gratitude to the Sponsors 00:05:28 Testosterone Replacement Therapy 00:10:09 Human Growth Hormone 00:13:56 Peptide Supplementation and Regenerative Signaling 00:18:11 MOTS-c, Humanin, and Other Peptides 00:25:05 Exosome Therapy 00:31:56 A Primer on Stem Cells and Yamanaka Factors 00:37:59 Stem Cell Aging and Cord Blood Banking 00:41:42 The Therapeutic Potential of Stem Cells 00:43:37 Cellular Reprogramming 00:51:35 Resetting the Aging Clock 00:56:50 The Future Looks Bright 00:58:15 Next Week’s Episode: External Aging 00:58:36 Subscription and Support Options Links: Benefits and risks of testosterone treatment: https://bit.ly/35I3uTs Eunuchs are long-lived: https://bit.ly/3ukL1GU Longevity is enhanced in mice lacking growth hormone: https://go.nature.com/3AOTW4k MOTS-c and age-dependent physical decline in mice: https://go.nature.com/34aUgi6 Fatty liver disease, obesity, and an analog of MOTS-C: https://bit.ly/3Ho7GFE Humanin regulates lifespan and healthspan in mice: https://bit.ly/3Gy0lm1 Humanin ameliorates diabetes in mice: https://bit.ly/3ukiFw7 Mouse aging can be modulated via exosomes: https://go.nature.com/3oi0sM4 Exosomes and ulcer healing in older mice: https://bit.ly/3oEhPaf Generating induced pluripotent stem cells: https://bit.ly/3APMypv Vision loss after ocular injections: https://bit.ly/3L2yVIh Mesenchymal stem cells and human frailty: https://bit.ly/3s6kzxX Restoring vision loss in older mice: https://go.nature.com/335iysI Reversing epigenetic age in humans: https://bit.ly/342XXGJ Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.