In Episode 6 of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante discuss cosmetic aging and how to improve skin, nails, and hair. They talk about why superficial aging occurs and how external signs of aging are often a reflection of biological age. The latest science behind various beautifying therapies is highlighted, including newer interventions like low-level laser therapy and platelet-rich plasma injections. #DavidSinclair #Longevity #SkinCare Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair Levels - https://levels.link/sinclair InsideTracker - https://insidetracker.com/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Lifespan podcast website: https://www.lifespanpodcast.com/ Dr. David Sinclair Social: Instagram - https://www.instagram.com/davidsinclairphd Twitter - https://twitter.com/davidasinclair Facebook - https://www.facebook.com/davidsinclairphd Stay up to date with David's work to democratize biological age testing and insights: https://www.tallyhealth.com/ Matthew LaPlante's Social: Twitter - https://twitter.com/mdlaplante Timestamps: 00:00:00 Launching Episode Six: Combating Cosmetic Aging & Improving Skin, Nails & Hair 00:02:54 Estrogen, Progesterone, and Menopause 00:09:51 Thanking the Sponsors 00:12:57 The Pinch Test, Epidermal Thinning, and Foot Ulcers 00:18:29 Skin and Biological Aging 00:23:19 Cellular Senescence, Ultraviolet Light, and Skin Aging 00:28:15 Collagen, Keratin, and Skin Health 00:33:38 A Quick Aside about Nails 00:34:45 Autophagy and Retinoids 00:36:57 Resveratrol, NAD Boosters, and Hyaluronic Acid 00:41:44 Botox, Skin Peels, and Microneedling 00:43:28 No Duh Stuff: Sun Damage, Smoking, Alcohol, and Bad Food 00:45:42 Hair Loss and Hair Graying 00:49:45 Topical Treatments, Pills, and Dihydrotestosterone 00:55:19 Frickin Laser Beams: Low-level Laser Therapy 00:57:59 Platelet-rich Plasma (PRP) Injections 01:00:11 Hair Aging, Stress, and Gray Hair Reversal 01:06:11 Targeting Aging Upstream 01:07:37 Today’s Takeaways 01:09:25 Subscription and Support Options Links: Human faces and mortality predictions: https://bit.ly/3rA0tgd Biological age prediction in human skin: https://bit.ly/3LdDZcO Senescent cells and lifespan in mice: https://go.nature.com/3HFO9Rh Nail growth and aging: https://bit.ly/34tnSYb Autophagy is a major regulator of aging: https://bit.ly/3uHh2Jr Hyaluronan and cancer resistance: https://go.nature.com/3HHoyHK Topical tretinoin and hair growth: https://bit.ly/3GCF0rl Dihydrotestosterone levels correlate with mortality: https://bit.ly/3GBFFJJ Eunuchs are especially long-lived: https://bit.ly/3ukL1GU Human hair greying is linked to life stress: https://bit.ly/3J5adVU Grey hair reversal in mice: https://bit.ly/3Li9F0J Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.