In 2013 I got the chance to film in medical research laboratories around the USA for Lab TV (800 videos produced in one year!). Every lab was in its own way, a fascinating story. In each case of course, I hoped for a successful result. These doctors were doing something very interesting that I believe was successful. This video shows the two leading research doctors in the process of finding something meaningful for those dealing with sugar in the body Dr. Steven Kliewer is a distinguished researcher known for his work in the field of molecular biology, particularly in relation to metabolism, diabetes, and the action of various hormones. His research has significantly contributed to the understanding of how the body regulates glucose and lipid metabolism, which are critical in the development and management of metabolic diseases such as diabetes. Dr. Kliewer's work often focuses on nuclear receptors, which are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones, as well. One of Kliewer’s notable contributions to science is his co-discovery of fibroblast growth factor 21 (FGF21), a hormone that has been shown to regulate glucose and lipid metabolism, and has potential therapeutic implications for obesity and diabetes. as certain other molecules. These receptors play a crucial role in regulating gene expression in response to these hormones, impacting a wide range of physiological processes including metabolism, development, and homeostasis. One of Kliewer’s notable contributions to science is his co-discovery of fibroblast growth factor 21 (shown in this video), a hormone that has been shown to regulate glucose and lipid metabolism, and has potential therapeutic implications for obesity and diabetes. His research has explored the mechanisms by which FGF21 and other hormones influence metabolic pathways, offering insights that could lead to new treatments for metabolic diseases. Fibroblast-growth factor 21 (FGF21) is thought to be important in metabolic regulation. Recently, low protein diets have been shown to increase circulating FGF21 levels. Circulating FGF21 levels are robustly increased by diets that are high in carbohydrate but low in protein, and exogenous FGF21 treatment reduces the consumption of sweet foods and alcohol while alternatively increasing the consumption of protein. Dr. David J. Mangelsdorf is a prominent scientist known for his groundbreaking work in the field of molecular biology, particularly regarding nuclear receptors, metabolism, and the hormonal regulation of various physiological processes. His research has made significant contributions to understanding how hormones regulate lipid and glucose metabolism, which are critical in the management of metabolic diseases such as diabetes. Dr. Mangelsdorf's work, often in collaboration with other researchers including Dr. Steven Kliewer, has led to the discovery and characterization of several nuclear receptors and their ligands, substances that bind to receptors and alter their activity. These discoveries have illuminated the roles of these receptors in controlling metabolic pathways, with implications for obesity, diabetes, cholesterol metabolism, and other metabolic diseases. One of the notable achievements in Dr. Mangelsdorf's career is the co-discovery of the liver X receptors (LXRs) and the identification of their role in cholesterol metabolism. Another significant contribution is his work on the Farnesoid X Receptor (FXR), which is involved in bile acid metabolism. His research has delved into the study of fibroblast growth factor 21 (FGF21), a hormone that Dr. Mangelsdorf and Dr. Kliewer's research showed to be a critical regulator of metabolism and has potential implications for treating diabetes and obesity. Dr. Mangelsdorf has received numerous awards and honors for his contributions to science, including election to the National Academy of Sciences. He holds an academic position at an into the leading university and is associated with various research institutions. His work is widely published in peer-reviewed journals, highlighting his role as a leader in the field of endocrinology and metabolism I do hope that those interested look further into the work done by these two doctors. If this was of interest to you, please support my efforts to present more videos like this by clicking the Thanks button below the video screen. Thank you.