Charles Brenner is a leading Global expert in the biology, chemistry and Medicine of NAD the central Catalyst of metabolism he currently works at City of Hope in Los Angeles as professor and chair of the Department of diabetes and cancer metabolism. I'm intrigued by Charles' recent rebuttal to David Sinclair's thesis regarding longevity. "Surtuins are not conserved longevity genes" published in the Journal of Life metabolism in October 2022. In this episode Charles and I discuss this paper and his view on the science of longevity. We will expand on this while also discussing various other topics related to NAD, use cases for NR, metabolism and where influencers go wrong in the nutrition space. If you have any additional questions you would like answered in the future, let me know in the comments. Optimise your health with InsideTracker’s biomarker analysis. Get exclusive access to InsideTracker’s new ApoB test, and a significant discount at http://insidetracker.com/louisa Chapters: 00:00:00 - The Role of NAD in Metabolism and Living Things 00:11:18 - NAD and the De Novo Pathway 00:21:50 - The Composition of NAD and NR 00:33:07 - The Innate Immune Response and NAD Churning 00:44:08 - The Longevity of Naked Mole Rats and Humans 00:55:27 - The Myth of Sirtuin Genes and Longevity 01:06:26 - Reproducibility Issues and False Claims 01:17:32 - Targeting the Aging System 01:27:44 - The Uselessness of Age Tests 01:38:26 - Q&A on Twitter Optimise your hydration and get a free sample pack of electrolytes at http://drinklmnt.com/neuro Connect with Dr Charles Brenner: - Twitter: https://twitter.com/CharlesMBrenner - Website: https://www.brennerlab.net/ The best way to support the show is to use the products and services offered by our sponsors. Connect with Dr Charles Brenner: - Twitter: https://twitter.com/CharlesMBrenner - Website: https://www.brennerlab.net/ *** The Neuro Athletics Newsletter: https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_