The smallest viruses with DNA genomes encode just one protein to enable replication by the cell’s DNA synthesis machinery. In contrast, some large DNA viruses encode complete DNA replication systems. In this session we reveal the mechanisms of DNA replication, including how origin-binding proteins recruit the host synthetic apparatus, replication by strand displacement or a replication fork, solving the 5'-end problem caused by RNA priming, and how viral genomes ensure that cells are actively duplicating their DNA to provide access to the DNA synthesis machinery. Virology Live 2021 Course Syllabus: https://www.virology.ws/virology-live-2021/ Virology Live 2021 Socrative Quiz Link (only during Livestream) https://b.socrative.com/login/student Room Name: Virus Become a patron of Virology Live at microbe.tv/contribute ——————————— CONNECT ——————————— 🎯 Subscribe! https://bit.ly/2HOYdNP Instagram: @profvrr and @microbe.tv Twitter: @profvrr Facebook: http://facebook.com/thisweekinvirology Our Podcasts: https://microbe.tv/ Contribute: https://www.microbe.tv/contribute/ ——————————— MORE VIROLOGY ——————————— •My Virology Course https://virology.ws/course •Virology Blog: https://www.virology.ws/ •This Week in Virology https://bit.ly/30uUhrX •Virus Watch https://bit.ly/3ngvQIM •Principles of Virology textbook https://amzn.to/34onDtg ——————————— OUR OTHER PODCASTS ——————————— •This Week in Parasitism https://bit.ly/3ndUNUZ •This Week in Microbiology https://bit.ly/33tOUeO •Urban Agriculture http://microbe.tv/urbanag •This Week in Evolution https://bit.ly/3ne1bf5 •Immune https://bit.ly/2HOyCVb •This Week in Neuroscience https://bit.ly/2So12Yd – Who Am I? – I’m Vincent Racaniello, Earth’s Virology Professor. I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more. New videos are uploaded every Thursday and Sunday mornings. I do not run ads on our work as it is disruptive to learning. We depend on your support. If you would like to support our work, go over to https://www.microbe.tv/contribute/ ——————————————————————— #microbe #viruses #lecture #COVID-19 ———————————————————————