Presented By: Cai Roberts, PhD Speaker Biography: Cai is an Assistant Professor of Pharmacology at Midwestern University in Downers Grove, IL. His laboratory focuses on epithelial to mesenchymal transition (EMT), a developmental process that is reactivated in cancer cells to drive tumor progression. His past work as a PhD student at City of Hope and an American Cancer Society Postdoctoral Fellow at Yale School of Medicine focused on the role of EMT in tumor metastasis and drug responses in ovarian cancer. Webinar: Epithelial-Mesenchymal Transition in the Crosshairs: Novel Treatments to Kill Drug Resistant, Metastatic Cells in Cancer Webinar Abstract: Across many cancers, mortality is associated with metastasis and acquired drug resistance, both of which often manifest in recurrent disease. Central to these phenomena is epithelial to mesenchymal transition (EMT), a developmental process reactivated during tumor progression. During EMT, transcriptional regulation of cell adhesion and cytoskeletal genes is altered, and cells become motile. For many years, EMT has been closely tied to metastasis, but in recent years its roles in drug resistance and stem cell phenotype have also been uncovered. While EMT is thus an attractive therapeutic target, progress in drug development for EMT has been limited, as the transcription factors that mediate the process have been dubbed “undruggable”. Novel approaches are therefore needed. Earn PACE Credits: 1. Make sure you’re a registered member of Labroots (https://www.labroots.com/ms/webinar/epithelial-mesenchymal-transition-crosshairs-novel-treatments-kill-drug-resistant-metastatic-cells-c) 2. Watch the webinar on YouTube or on the Labroots Website (https://www.labroots.com/ms/webinar/epithelial-mesenchymal-transition-crosshairs-novel-treatments-kill-drug-resistant-metastatic-cells-c) 3. Click Here to get your PACE credits (Expiration date – February 21, 2026): (https://www.labroots.com/credit/pace-credits/8506/cert) Labroots on Social: Facebook: https://www.facebook.com/LabRootsInc Twitter: https://twitter.com/LabRoots LinkedIn: https://www.linkedin.com/company/labroots Instagram: https://www.instagram.com/labrootsinc Pinterest: https://www.pinterest.com/labroots/ SnapChat: labroots_inc