This video is brought to you by the American Lung Cancer Screening Initiative (ALCSI). Visit their website at http://healthcare.nucleusmedicalmedia.com/alcsi-ANH12071 for free educational resources and webinars on lung cancer and lung cancer screening. For Employees of Hospitals, Schools, Universities and Libraries: Download 8 FREE medical animations from Nucleus by signing up for a free trial: https://tinyurl.com/3n8hyrmc Biology students: Subscribe to the Nucleus Biology channel to see new animations on biology and other science topics, plus short quizzes to ace your next exam: https://bit.ly/3lH1CzV Every time you smoke a cigarette, toxic gases pass into your lungs, then into your bloodstream where they spread to every organ in your body. A cigarette is made using the tobacco leaf, which contains nicotine and a variety of other compounds. As the tobacco and compounds burn, they release thousands of dangerous chemicals, including over 40 known to cause cancer. Cigarette smoke contains the poisonous gases carbon monoxide and nitrogen oxide, as well as trace amounts of cancer-causing radioactive particles. All forms of tobacco are dangerous, including cigars, pipes, and smokeless tobacco, such as chewing tobacco and snuff. Nicotine is an addictive chemical in tobacco. After you inhale tobacco smoke, nicotine flows through the bloodstream to your brain, where it induces a pleasurable feeling. When you repeatedly expose your brain to nicotine, it becomes desensitized, making you crave more and more nicotine just to feel normal. Smoking causes death. People who smoke typically die at an earlier age than nonsmokers. In fact, one of every five deaths in the United States is linked to cigarette smoking. If you smoke, your risk of major health problems increases dramatically, including heart disease, heart attack, stroke, lung cancer, and death from chronic obstructive pulmonary disease. Smoking causes cardiovascular disease. When nicotine flows through your adrenal glands, it stimulates the release of epinephrine, a hormone that raises your blood pressure. In addition, nicotine and carbon monoxide can damage the lining of the inner walls in your arteries. Fatty deposits, called plaque, can build up at these injury sites and become large enough to narrow the arteries and severely reduced blood flow, resulting in a condition called atherosclerosis. In coronary artery disease, atherosclerosis narrows the arteries that supply the heart, which reduces the supply of oxygen to your heart muscle, increasing your risk for a heart attack. Smoking also raises your risk for blood clots, because it causes platelets in your blood to clump together. Smoking increases your risk for peripheral vascular disease, in which atherosclerotic plaques block the large arteries in your arms and legs. Smoking can also cause an abdominal aortic aneurysm, which is a swelling or weakening of your aorta, where it runs through your abdomen. Smoking damages two main parts of your lungs. Your airways, also called bronchial tubes, and small air sacs called alveoli. With each breath, air travels down your windpipe, called the trachea, and enters your lungs through your bronchial tubes. Air then moves into thousands of tiny alveoli, where oxygen from the air moves into your bloodstream, and the waste product, carbon dioxide, moves out of your bloodstream. Tiny hair like projections, called cilia, line your bronchial tubes and sweet harmful substances out of your lungs. Cigarette smoke irritates the lining of your bronchial tubes, causing them to swell and make mucus. Cigarette smoke also slows the movement of your cilia, causing some of the smoke and mucus to stay in your lungs. While you are sleeping, some of the cilia recover and start pushing more pollutants and mucous out of your lungs. When you wake up, your body attempts to expel this material by coughing repeatedly, a condition known as smoker's cough. Over time, chronic bronchitis develops. Chronic bronchitis and emphysema are collectively called chronic obstructive pulmonary disease, or COPD. COPD is a gradual loss of the ability to breathe for which there is no cure. Cigarette smoke contains at least 40 cancer causing substances, called carcinogens, including cyanide, formaldehyde, benzene, and ammonia. In your body, healthy cells grow, make new cells, then die. Genetic material inside each cell, called DNA, directs this process. If you smoke, toxic chemicals can damage the DNA in your healthy cells. As a result, your damaged cells create new, unhealthy cells, which grow out of control and may spread to other parts of your body. The most common cancer in the world is lung cancer, with over a million new cases diagnosed every year... ANH12071