Cystic fibrosis-related diabetes (CFRD) is one of the most common co-morbidities seen in CF. Morbidity and mortality increase significantly when CFRD is diagnosed. Unfortunately, the exact mechanisms leading to the development of CFRD are incompletely understood. One heavily debated mechanism pertaining to the etiology of CFRD is based upon CFTR expression within the beta cell, leading to intrinsic beta cell impairment. An alternative explanation is derived from extrinsic factors, like severe exocrine pancreatic pathology causing endocrine pancreatic dysfunction. Speakers for this session explore the unique relationship between the endocrine and exocrine pancreas, and the possible interplay they may have on dysglycemia in CF. Xingshen Sun, PhD, University of Iowa, discusses the use of CFTR modulator therapy on the endocrine pancreas in the CF ferret model. Rebecca Hull-Meichle, PhD, University Washington, focuses on the CF pancreas with special attention paid to the interaction between the endocrine and exocrine pancreas. Eddie James, PhD, Benaroya Research Institute, discuss beta cell reactive T-cells in CFRD. Finally, Katie Larson Ode, MD, University of Iowa, MD, explores the role of glycemic phenotyping for people with CF who do not have CFRD. Originally recorded November 2, 2023.