Fighting any of these bosses alone would be a challenge, but as duo, these pairs are nightmares. For this list, we’ll be looking at games that upped the difficulty by having you face two bosses at once. Our countdown includes Theseus & Asterius from “Hades” (2020), Caroline & Justine from “Persona 5” (2017), Agni & Rudra from “Devil May Cry 3: Dante’s Awakening” (2005), Master Hand & Crazy Hand from “Super Smash Bros. Melee” (2001), and more! Have you faced any of these duos? Which frustrated you the most? Share your thoughts in the comments below. Watch more videos on great boss fights here: Top 10 Greatest Video Game Bosses From The 2010s: https://www.youtube.com/watch?v=CaVxNACOurs Top 10 Greatest Video Game Bosses From The 2000s: https://www.youtube.com/watch?v=8vY-d6P9z5I Top 10 Greatest Video Game Bosses From The 90s: https://www.youtube.com/watch?v=j_uT8IrmHNI Test your Trivia Power! https://www.watchmojo.com/play/id/54751 Have Your Idea Become A Video! https://wmojo.com/suggest Subscribe for more great content! https://wmojo.com/watchmojo-subscribe Visit WatchMojo Club for Great Deals! https://wmojo.com/WatchMojoClub Your trusted authority for Top 10 lists, reviews, tips and tricks, biographies, origins, and entertainment news on Film, TV, Video Games, Comics, Celeb, Music and Superheroes. #Gaming #VideoGames #Boss #Games #PlayStation #Nintendo #Xbox #FinalFantasy #EldenRing #Hades