NIH Science in Seconds – a weekly roundup of NIH’s research news. Read more about each of the featured news stories below. Week of May 29, 2023: 1. NIH has launched a large precision medicine cancer initiative to test the effectiveness of new drug combinations that target specific tumor alterations. The initiative is the largest of its kind to test combinations of cancer drugs guided by tumor biology. https://bit.ly/3CbiDcI 2. NIH researchers discovered genomic variants that cause a rare and severe inflammatory skin disorder, known as disabling pansclerotic morphea. The study also identified a drug to target an important feedback loop that significantly improved symptoms in patients. https://bit.ly/3qtoyXZ 3. A case study in a brother and sister has led to the discovery of a new gene variant that affords protection against Alzheimer's disease. The Reelin pathway and brain region as promising targets for future study and development of Alzheimer’s treatments. https://bit.ly/3IXKjpl