In this session, Michaela Johnson presents on olfactory perceptual function by monitoring odor-evoked sniffing behavior in a plethysmograph at one-, three- and six-months after bilateral injections of α-syn preformed fibrils into the olfactory bulb. She reports that at all-time points, females injected with fibrils exhibited reduced odor detection sensitivity, which was detectable with the semi-automated plethysmography apparatus, but not a buried pellet test. Our second speaker, Aishwarya Kulkarni discusses using local field potential recordings to monitor neural activity in awake mice as they were delivered odors, following injection of α-syn preformed fibrils into the olfactory bulb. She reports this work uncovered that a-Syn pathology in the olfactory system impacts in vivo neural activity in specific manners. Webinar 13_210520.