When you think of antihistamines, you're probably only thinking about getting rid of a runny nose, congestion or a common cold. However we're learning that antihistamines can be used for nausea, insomnia, and even... depression? Join Hank and learn more in this new episode of SciShow! SciShow is on TikTok! Check us out at https://www.tiktok.com/@scishow ---------- Support SciShow by becoming a patron on Patreon: https://www.patreon.com/scishow ---------- Huge thanks go to the following Patreon supporters for helping us keep SciShow free for everyone forever: Bryan Cloer, Chris Peters, Matt Curls, Kevin Bealer, Jeffrey Mckishen, Jacob, Christopher R Boucher, Nazara, charles george, Christoph Schwanke, Ash, Silas Emrys, Eric Jensen, Adam Brainard, Piya Shedden, Alex Hackman, James Knight, GrowingViolet, Sam Lutfi, Alisa Sherbow, Jason A Saslow, Dr. Melvin Sanicas, Melida Williams, Tom Mosner ---------- Sources: http://www3.uah.es/farmamol/The%20Pharmaceutical%20Century/Ch1.html https://pubmed.ncbi.nlm.nih.gov/11319582/ https://pubmed.ncbi.nlm.nih.gov/24925379/ https://www.eurekaselect.com/184311/article https://doi.org/10.1046/j.1365-2222.1999.00004.x-i1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1760721/ https://medlineplus.gov/medlineplus-videos/histamine-the-stuff-allergies-are-made-of/ https://www.jstor.org/stable/25402552 https://doi.org/10.5114/aoms.2017.68534 https://europepmc.org/article/NBK/nbk538188 https://www.frontiersin.org/articles/10.3389/fimmu.2018.01873/full https://pubmed.ncbi.nlm.nih.gov/15544559/ https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/bph.14524 https://www.jbc.org/article/S0021-9258(20)88583-4/fulltext https://doi.org/10.3389/fnsys.2012.00072 https://pubmed.ncbi.nlm.nih.gov/15544559/ https://www.ncbi.nlm.nih.gov/books/NBK526010/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016451/ https://academic.oup.com/cid/article/33/9/1483/413500 https://medlineplus.gov/druginfo/meds/a601106.html https://www.mdpi.com/journal/ijms/special_issues/histamine_systems https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425212/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463562/ https://doi.org/10.1016/j.biopsych.2018.11.009 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992892/ Image Sources: https://www.istockphoto.com/photo/little-red-pills-gm89289835-3245533 https://www.istockphoto.com/photo/woman-sneezing-in-park-with-flowers-in-other-hand-gm948937692-259054562 https://www.istockphoto.com/photo/egyptian-pharoah-gm95243252-4404058 https://www.istockphoto.com/photo/spectacular-jellyfish-gm844242062-138966043 https://www.istockphoto.com/photo/allergy-concept-young-asian-woman-sneezes-and-blowing-her-nose-with-a-handkerchief-gm1145673155-308446649 https://commons.wikimedia.org/wiki/File:Ergot01.jpg https://www.istockphoto.com/photo/guinea-pig-gm1313503414-401985551 https://www.istockphoto.com/photo/histamine-about-to-bind-to-the-histamine-receptor-gm858663912-141779979 https://commons.wikimedia.org/wiki/File:H1_Receptor_with_Doxepin.png https://www.istockphoto.com/photo/human-stomach-anatomy-gm1127591138-297249850 https://www.istockphoto.com/photo/3d-rendering-illustration-bright-glossy-brain-on-light-blue-bg-gm1276513584-376006793 https://www.istockphoto.com/photo/mast-cell-releasing-histamine-gm979449686-266152097 https://www.istockphoto.com/photo/tired-young-woman-sleeping-on-couch-at-home-gm1258280097-368967365 https://www.istockphoto.com/photo/white-mouse-in-white-maze-looking-over-walls-gm636373812-112867845 https://www.istockphoto.com/photo/springtime-allergy-woman-sneezing-on-the-city-street-gm1231848514-362235319 https://www.istockphoto.com/vector/sneezing-flat-color-vector-faceless-character-woman-with-nasal-sickness-female-gm1301756352-393704231 https://www.istockphoto.com/vector/ragweed-plant-gm844121526-138130959 https://www.istockphoto.com/vector/mast-cell-or-a-mastocyte-labrocyte-gm500393403-42866878 https://www.istockphoto.com/photo/dust-pollen-and-small-particles-fly-through-the-air-in-the-sunshine-gm1147755937-309723635 https://www.istockphoto.com/photo/antihistamine-drug-loratadine-gm492572037-40597734 https://commons.wikimedia.org/wiki/File:Ranitidine-B-3D-balls.png https://www.istockphoto.com/vector/pills-vector-illustration-gm1184148312-333206316 https://www.istockphoto.com/vector/man-feel-dizzy-line-icon-tired-man-with-nausea-outline-icon-dizziness-migraine-gm1343864091-422418575 https://www.istockphoto.com/vector/flu-disease-prevention-cold-symptoms-flat-line-icons-set-fever-headache-sneeze-sore-gm1182393306-331998605 https://www.istockphoto.com/vector/flat-outline-covid-19-coronavirus-viral-prevention-icons-gm1265233204-370789987 https://www.istockphoto.com/vector/allergies-allergic-diseases-linear-icon-set-allergic-reaction-to-an-allergen-line-gm1243194010-362848724 https://www.istockphoto.com/vector/eye-sore-line-and-glyph-icon-disease-and-allergy-eye-redness-vector-icon-vector-gm1310400998-399817305